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helena

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Dose-dependent pharmacokinetics of ibuprofen in the rat.
Shah A, Jung D.
Abstract
The linearity of the pharmacokinetics of ibuprofen was examined in male Sprague-Dawley rats given iv bolus doses of 10, 20, and 50 mg/kg ibuprofen. Plasma and urine concentrations of ibuprofen and its two major metabolites, OH-ibuprofen and COOH-ibuprofen, were determined by HPLC and the binding of ibuprofen to plasma proteins was measured by an ultrafiltration technique. The systemic plasma clearance (CLtot) of ibuprofen was dose-dependent and decreased from 0.29 to 0.14 liter/hr/kg primarily as a result of a 65% decrease in the partial metabolic clearance to OH-ibuprofen while the average mean residence time (MRTtot) increased approximately 35% over the 10-50 mg/kg dosage range. Since there were no dose-dependent changes in the apparent steady state volume of distribution (Vss,tot), the mean harmonic half-life increased from 1.7-2.8 hr over the dosage range studied. The binding of ibuprofen to plasma proteins was relatively independent of concentration up to 90 mg/liter (mean free fraction approximately 5.5%), but became markedly concentration-dependent thereafter (free fraction up to 25.4% at 411 mg/liter). The mean recovery of total ibuprofen in the urine over 24 hours at 10 mg/kg was 62.1% and decreased by 24% and 40% at 50 and 20 mg/kg, respectively. This dose-dependent decrease in the percentage excreted in the urine was primarily due to a reduction in the recovery of OH-ibuprofen slightly offset by a small, but significant, increase in the urinary excretion of COOH-ibuprofen between 10 and 50 mg/kg. The apparent pharmacokinetic parameters based on free, unbound concentrations of ibuprofen were also dose-dependent.(ABSTRACT TRUNCATED AT 250 WORDS)
PMID:
2882970
[PubMed - indexed for MEDLINE]
 
سلام کسی میتونه فول تکست این مقاله رو برای من بگیره یا راهنماییم کنه چکار کنم؟
Dose-dependent pharmacokinetics of ibuprofen in the rat.
Shah A, Jung D.
Abstract
The linearity of the pharmacokinetics of ibuprofen was examined in male Sprague-Dawley rats given iv bolus doses of 10, 20, and 50 mg/kg ibuprofen. Plasma and urine concentrations of ibuprofen and its two major metabolites, OH-ibuprofen and COOH-ibuprofen, were determined by HPLC and the binding of ibuprofen to plasma proteins was measured by an ultrafiltration technique. The systemic plasma clearance (CLtot) of ibuprofen was dose-dependent and decreased from 0.29 to 0.14 liter/hr/kg primarily as a result of a 65% decrease in the partial metabolic clearance to OH-ibuprofen while the average mean residence time (MRTtot) increased approximately 35% over the 10-50 mg/kg dosage range. Since there were no dose-dependent changes in the apparent steady state volume of distribution (Vss,tot), the mean harmonic half-life increased from 1.7-2.8 hr over the dosage range studied. The binding of ibuprofen to plasma proteins was relatively independent of concentration up to 90 mg/liter (mean free fraction approximately 5.5%), but became markedly concentration-dependent thereafter (free fraction up to 25.4% at 411 mg/liter). The mean recovery of total ibuprofen in the urine over 24 hours at 10 mg/kg was 62.1% and decreased by 24% and 40% at 50 and 20 mg/kg, respectively. This dose-dependent decrease in the percentage excreted in the urine was primarily due to a reduction in the recovery of OH-ibuprofen slightly offset by a small, but significant, increase in the urinary excretion of COOH-ibuprofen between 10 and 50 mg/kg. The apparent pharmacokinetic parameters based on free, unbound concentrations of ibuprofen were also dose-dependent.(ABSTRACT TRUNCATED AT 250 WORDS)
PMID:
2882970
[PubMed - indexed for MEDLINE]

به نویسنده اش ایمیل بزنید تا براتون بفرسته...اگه یه توضیح کوتاه بدین که کجا و چرا لازم دارین این مقاله رو احتمال اینکه بفرسته خیلی زیاد هست.

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سلام کسی میتونه فول تکست این مقاله رو برای من بگیره یا راهنماییم کنه چکار کنم؟
Dose-dependent pharmacokinetics of ibuprofen in the rat.
Shah A, Jung D.
Abstract
The linearity of the pharmacokinetics of ibuprofen was examined in male Sprague-Dawley rats given iv bolus doses of 10, 20, and 50 mg/kg ibuprofen. Plasma and urine concentrations of ibuprofen and its two major metabolites, OH-ibuprofen and COOH-ibuprofen, were determined by HPLC and the binding of ibuprofen to plasma proteins was measured by an ultrafiltration technique. The systemic plasma clearance (CLtot) of ibuprofen was dose-dependent and decreased from 0.29 to 0.14 liter/hr/kg primarily as a result of a 65% decrease in the partial metabolic clearance to OH-ibuprofen while the average mean residence time (MRTtot) increased approximately 35% over the 10-50 mg/kg dosage range. Since there were no dose-dependent changes in the apparent steady state volume of distribution (Vss,tot), the mean harmonic half-life increased from 1.7-2.8 hr over the dosage range studied. The binding of ibuprofen to plasma proteins was relatively independent of concentration up to 90 mg/liter (mean free fraction approximately 5.5%), but became markedly concentration-dependent thereafter (free fraction up to 25.4% at 411 mg/liter). The mean recovery of total ibuprofen in the urine over 24 hours at 10 mg/kg was 62.1% and decreased by 24% and 40% at 50 and 20 mg/kg, respectively. This dose-dependent decrease in the percentage excreted in the urine was primarily due to a reduction in the recovery of OH-ibuprofen slightly offset by a small, but significant, increase in the urinary excretion of COOH-ibuprofen between 10 and 50 mg/kg. The apparent pharmacokinetic parameters based on free, unbound concentrations of ibuprofen were also dose-dependent.(ABSTRACT TRUNCATED AT 250 WORDS)
PMID:
2882970
[PubMed - indexed for MEDLINE]

به نویسنده اش ایمیل بزنید تا براتون بفرسته...اگه یه توضیح کوتاه بدین که کجا و چرا لازم دارین این مقاله رو احتمال اینکه بفرسته خیلی زیاد هست.
 

helena

New member
به نویسنده اش ایمیل بزنید تا براتون بفرسته...اگه یه توضیح کوتاه بدین که کجا و چرا لازم دارین این مقاله رو احتمال اینکه بفرسته خیلی زیاد هست.

- - - Updated - - -


بهش ایمیل زدم ولی نفرستاد برام..........



به نویسنده اش ایمیل بزنید تا براتون بفرسته...اگه یه توضیح کوتاه بدین که کجا و چرا لازم دارین این مقاله رو احتمال اینکه بفرسته خیلی زیاد هست.


بهش ایمیل زدم ولی نفرستاد برام
 

sinasina

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سلام. چنانچه هنوز مقاله را پیدا نکرده اید، doi آن را برای من بفرستید تا full-text آن را برایتان ارسال کنم.
 

biosta

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به لینک زیر هم سری بزنید مطالب ارزشمندی خواهید یافت .
http://olumpezeshki.ir/thread5382-2.html#post430008

 
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واکنش‌ها[ی پسندها]: IL-2

sinasina

New member
بهش ایمیل زدم ولی نفرستاد برام

مقاله مربوط به سال 1987 است و doi ندارد. قاعدتا خود نویسندگان این مقاله هم از در سال 2014 از ایمیلی که برای آن مقاله نوشته اند، استفاده نمی کنند. سعی کنید خود خود این اساتید را در گوگل سرچ فرمایید، شاید توانستید ایمیل جدیدی از آن ها پیدا کنید.
 

helena

New member
سلام. چنانچه هنوز مقاله را پیدا نکرده اید، doi آن را برای من بفرستید تا full-text آن را برایتان ارسال کنم.

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